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We found no reduction in the risk of cardiovascular or renal events or death in patients who were receiving darbepoetin alfa, as compared with those receiving placebo, but we found nearly a doubling in the risk of stroke.

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For lack or loss of hemoglobin response to darbepoetin alfa, initiate a search for causative factors (e.

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If no alternative cause for the anemia is found, therapy with erythropoietin-stimulating agents (ESAs) is initiated usually at a nephrologist's office.

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