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The US Food and Drug Administration reconvened ODAC in May 2007, after the release of results from subsequent trials that raised additional safety concerns.
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Before the initiation of erythropoietin replacement, nonrenal causes of anemia need to be excluded.
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Because some cancer cells express EPO-R, treatment with epoetin alfa could produce a variety of direct effects on tumors.
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The hemoglobin levels conform to the general pattern of response and also show wide fluctuations in individual patients in response to adjustment of the dose of erythropoietin.
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