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This medicine may increase your risk of having blood clots, especially in patients who use epoetin alfa before a major surgery.
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Additional serious adverse reactions that occurred in less than 5% of epoetin alfa-treated patients not on dialysis and greater than placebo were erythema (0.
Anemia in chronic kidney disease patients: treatment recommendations and emerging therapies.
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Effect of normovolemic hematocrit changes on blood pressure and flow.
These analyses are consistent with recent FDA guidelines which require instrument development and validation testing for children and adolescents within fairly narrow age groupings and which determine the lower age limit at which children can provide reliable and valid responses across age categories.
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The FDA-approved label states that ESAs are not indicated for patients receiving curative myelosuppressive chemotherapy.
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Affect Disord 36 (1-2): 11-20, 1995.
Servaes P, Verhagen S, Bleijenberg G: Determinants of chronic fatigue in disease-free breast cancer patients: a cross-sectional study.
Detection of DNA-recombinant human epoetin-alfa as a pharmacological ergogenic aid.
The US Food and Drug Administration reconvened ODAC in May 2007, after the release of results from subsequent trials that raised additional safety concerns.
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Epoetin alfa for chemotherapy- or radiotherapy-induced anemia has been evaluated by many investigators.
If you are using epoetin alfa at home, store epoetin alfa as directed by your pharmacist or health care provider.
Effect of alternate night nocturnal home hemodialysis on anemia control in patients with end-stage renal disease.
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Because myelodysplastic syndromes can affect your immune system, try to avoid close contact with anyone who is sick, including family members and co-workers.
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Concomitant deep venous thrombosis (DVT) prophylaxis is recommended.
Before the initiation of erythropoietin replacement, nonrenal causes of anemia need to be excluded.
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Epoetin alfa alleviates anemia that can be caused by chemotherapy by increasing low levels of red blood cells to normal levels.
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The same quantitative test should be used throughout therapy to avoid confusion, and results should be reported in international units (IU) to standardize data.
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Intersecting guidelines: Administering erythropoiesis-stimulating agents to chronic kidney disease patients with cancer.
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The FACIT Measurement System offers several benefits to an investigator seeking to measure HRQOL in people with cancer, HIV disease, multiple sclerosis, arthritis and other conditions.
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The short-term use of erythropoetin-stimulating agents: impact on the biochemical recurrence of prostate cancer.
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Because some cancer cells express EPO-R, treatment with epoetin alfa could produce a variety of direct effects on tumors.
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The hemoglobin levels conform to the general pattern of response and also show wide fluctuations in individual patients in response to adjustment of the dose of erythropoietin.
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However, due to certain coding conventions mainly used in Part A of Medicare, this LCD will express hematocrits as a measure of anemia.
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The first commercial rHuEpo product introduced in the United States and European Union was Epoetin alfa and tests were developed to detect this molecule.
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Withhold dose if Hgb exceeds a level needed to avoid RBC transfusion and reinitiate at a dose 25% below the previous dose when Hgb approaches a level in which RBC transfusion may be required.
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For HCV-monoinfected patients with genotypes 2 or 3, ribavirin at 800 mg daily may be sufficient.
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In addition, immune reconstitution with HAART might improve: (i) the natural history of HCV-related liver disease in the long term or (ii) the response to HCV treatment.
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Intensity of chemotherapy in the above trials was not directly assessed, however the degree and timing of neutropenia was comparable across all trials.
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