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Unlike drugs with “pure” class III effect (eg, d-sotalol, dofetilide), the effect of amiodarone on APD and ERP is not reverse-use dependent, and the effect is preserved at high heart rates.
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In patients who experience AF-related symptoms during activity, the adequacy of heart rate control should be assessed during exertion, adjusting pharmacological treatment as necessary to keep the ventricular rate within the physiological range.
Supplemental infusions (150 mg) of intravenous amiodarone could be given to treat breakthrough ventricular arrhythmias.
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Slow sinus as well as av nodal conduction which results in decrease in HR and increase PR atrial depolarization, QT and QRS are not significantly altered.
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