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Substances Increasing the Systemic Exposure of COCs (enzyme inhibitors): The effect of a strong CYP3A4 inhibitor, ketoconazole, on dienogest and estradiol exposure was studied in an open-label, one-sequence, one-way crossover study in healthy postmenopausal Caucasian women.
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IT IS UNKNOWN WHETHER THIS FINDING APPLIES TO YOUNGER POSTMENOPAUSAL WOMEN.
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